Effect of Fluorosis on Hepatic Enzymes in Human

Fluorosis is a major public health problem in India. This cross-sectional observational study has been conducted in the fluoride endemic zones of Bankura district to evaluate the effect of fluorosis on the liver enzymes. This study was carried out in the Simlapal block of Bankura, on 100 subjects by using simple random sampling in which 50 were cases. The serum samples were collected from the subjects and serum fluoride was estimated by Ion-Meter and serum ALT, AST, ALP and LDH levels were determined by auto-analyzer and were compared with age and sex matched controls. The serum fluoride was found to have a statistically significant relationship with AST and ALP and serum LDH has also statistically significant relationship with ALT and AST in the study group. The serum levels of fluoride, ALT, AST, ALP and LDH were higher in the study group compared to the comparison group.